Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
USERS' SCORE
Good
Based on 9 Reviews
8.6
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
<1%**
Sodium
150 mg
7%
Glucosamine Sulfate(from 1,500 mg Glucosamine PotassiumSulfate Complex)
1.1 g (1,100 mg)
†
Chondroitin Sodium Sulfate(from Bovine Cartilage)
1.2 g (1,200 mg)
†
MSM (Methylsulfonylmethane)
300 mg
†
Top Medical Research Studies
9
We investigated how glucosamine sulfate, especially in combination with vitamin E, affects rheumatoid arthritis (RA) using a neonatal rat model. Through our study, we measured various biological markers, including lipid peroxidation, antioxidant levels, and inflammatory factors to understand better how this treatment could help counteract the effects of RA.
Our findings showed that when glucosamine was paired with vitamin E, there was a notable reduction in the levels of malondialdehyde (MDA), a marker of oxidative stress. Specifically, we observed a reduction of 61.9% in MDA levels, which suggests a positive effect on oxidative stress associated with RA. Additionally, key antioxidants like superoxide dismutase (SOD), catalase, and glutathione were elevated, indicating improved antioxidant activity.
We also noted significant decreases in various inflammatory markers, including matrix metalloproteinase-3 (MMP-3) and prostaglandin E (PGE), suggesting that this combination therapy may effectively reduce inflammation related to RA. The results indicated a synergistic effect between glucosamine and vitamin E in mitigating symptoms of RA, highlighting potential benefits for those grappling with this condition.
Our findings showed that when glucosamine was paired with vitamin E, there was a notable reduction in the levels of malondialdehyde (MDA), a marker of oxidative stress. Specifically, we observed a reduction of 61.9% in MDA levels, which suggests a positive effect on oxidative stress associated with RA. Additionally, key antioxidants like superoxide dismutase (SOD), catalase, and glutathione were elevated, indicating improved antioxidant activity.
We also noted significant decreases in various inflammatory markers, including matrix metalloproteinase-3 (MMP-3) and prostaglandin E (PGE), suggesting that this combination therapy may effectively reduce inflammation related to RA. The results indicated a synergistic effect between glucosamine and vitamin E in mitigating symptoms of RA, highlighting potential benefits for those grappling with this condition.
Read More
9
Glucosamine combined reduces arthritis symptoms
We explored the effects of glucosamine sulfate in conjunction with methionine on adjuvant arthritis, a model used to study rheumatoid arthritis in rats. The study involved administering methionine and glucosamine either alone or together for 21 days after inducing arthritis in the rats.
Our findings showed that the combination of methionine and glucosamine significantly reduced joint swelling and improved arthritis scores compared to when either treatment was given alone. This combined approach also had a negative effect on the inflammatory response, as evidenced by reduced levels of substances linked to inflammation in the rats' blood.
However, it's important to note that using only glucosamine did not lead to significant improvements by itself. The results suggest that while glucosamine might have potential, its benefits are more pronounced when combined with methionine rather than when used independently.
Our findings showed that the combination of methionine and glucosamine significantly reduced joint swelling and improved arthritis scores compared to when either treatment was given alone. This combined approach also had a negative effect on the inflammatory response, as evidenced by reduced levels of substances linked to inflammation in the rats' blood.
However, it's important to note that using only glucosamine did not lead to significant improvements by itself. The results suggest that while glucosamine might have potential, its benefits are more pronounced when combined with methionine rather than when used independently.
Read More
8
We aimed to investigate how glucosamine sulfate (GS), chondroitin sulfate (CS), and their combination (GC) could help manage rheumatoid arthritis (RA) in rat models. After inducing RA in rats, we monitored their body weight and paw swelling at different times. The treatments started after confirming the RA model, allowing us to observe their effects on inflammation levels over time.
Our findings showed that only the combination treatment, GC, effectively reduced paw swelling and certain inflammatory markers in the joint tissue. Notably, this combined treatment seemed to target specific bacteria in the gut that may contribute to inflammation. We noticed that GC inhibited a group of bacteria linked to pro-inflammatory responses, providing a potential mechanism for its therapeutic effect.
The gut microbiota appears to play a significant role, as we found that restoring its balance coincided with reduced joint swelling. In summary, the combination of glucosamine and chondroitin sulfate offers a promising avenue for managing rheumatoid arthritis by regulating inflammation and improving gut health.
Our findings showed that only the combination treatment, GC, effectively reduced paw swelling and certain inflammatory markers in the joint tissue. Notably, this combined treatment seemed to target specific bacteria in the gut that may contribute to inflammation. We noticed that GC inhibited a group of bacteria linked to pro-inflammatory responses, providing a potential mechanism for its therapeutic effect.
The gut microbiota appears to play a significant role, as we found that restoring its balance coincided with reduced joint swelling. In summary, the combination of glucosamine and chondroitin sulfate offers a promising avenue for managing rheumatoid arthritis by regulating inflammation and improving gut health.
Read More
Most Useful Reviews
9.5
Significant health improvement
Glucosamine chondroitin is an excellent supplement. I have back issues and joint pain. After a week of use, my health improved remarkably. My mother took this supplement for rheumatoid arthritis alongside hormones, resulting in a good outcome with pain relief. We sourced this from another manufacturer, and this one is clearly superior in quality and dosage. I highly recommend it.
Read More
9.5
Reduced joint discomfort
This product works! I opted for Now among other brands. It provides excellent dosage with sulphur, sufficient for a three-month course. I bought it for my 56-year-old mother, who has rheumatoid arthritis, and within three weeks, her knees stopped crunching, and morning aches were less severe. We take this alongside collagen powder and multivitamins 55+.
Read More
9.5
Mobility restored
Following Covid, I experienced joint complications. This product has helped me live pain-free and restored my joint mobility, making rheumatoid arthritis a thing of the past.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
- All Researches
9
We investigated how glucosamine sulfate, especially in combination with vitamin E, affects rheumatoid arthritis (RA) using a neonatal rat model. Through our study, we measured various biological markers, including lipid peroxidation, antioxidant levels, and inflammatory factors to understand better how this treatment could help counteract the effects of RA.
Our findings showed that when glucosamine was paired with vitamin E, there was a notable reduction in the levels of malondialdehyde (MDA), a marker of oxidative stress. Specifically, we observed a reduction of 61.9% in MDA levels, which suggests a positive effect on oxidative stress associated with RA. Additionally, key antioxidants like superoxide dismutase (SOD), catalase, and glutathione were elevated, indicating improved antioxidant activity.
We also noted significant decreases in various inflammatory markers, including matrix metalloproteinase-3 (MMP-3) and prostaglandin E (PGE), suggesting that this combination therapy may effectively reduce inflammation related to RA. The results indicated a synergistic effect between glucosamine and vitamin E in mitigating symptoms of RA, highlighting potential benefits for those grappling with this condition.
Our findings showed that when glucosamine was paired with vitamin E, there was a notable reduction in the levels of malondialdehyde (MDA), a marker of oxidative stress. Specifically, we observed a reduction of 61.9% in MDA levels, which suggests a positive effect on oxidative stress associated with RA. Additionally, key antioxidants like superoxide dismutase (SOD), catalase, and glutathione were elevated, indicating improved antioxidant activity.
We also noted significant decreases in various inflammatory markers, including matrix metalloproteinase-3 (MMP-3) and prostaglandin E (PGE), suggesting that this combination therapy may effectively reduce inflammation related to RA. The results indicated a synergistic effect between glucosamine and vitamin E in mitigating symptoms of RA, highlighting potential benefits for those grappling with this condition.
Read More
9
Glucosamine combined reduces arthritis symptoms
We explored the effects of glucosamine sulfate in conjunction with methionine on adjuvant arthritis, a model used to study rheumatoid arthritis in rats. The study involved administering methionine and glucosamine either alone or together for 21 days after inducing arthritis in the rats.
Our findings showed that the combination of methionine and glucosamine significantly reduced joint swelling and improved arthritis scores compared to when either treatment was given alone. This combined approach also had a negative effect on the inflammatory response, as evidenced by reduced levels of substances linked to inflammation in the rats' blood.
However, it's important to note that using only glucosamine did not lead to significant improvements by itself. The results suggest that while glucosamine might have potential, its benefits are more pronounced when combined with methionine rather than when used independently.
Our findings showed that the combination of methionine and glucosamine significantly reduced joint swelling and improved arthritis scores compared to when either treatment was given alone. This combined approach also had a negative effect on the inflammatory response, as evidenced by reduced levels of substances linked to inflammation in the rats' blood.
However, it's important to note that using only glucosamine did not lead to significant improvements by itself. The results suggest that while glucosamine might have potential, its benefits are more pronounced when combined with methionine rather than when used independently.
Read More
8
We aimed to investigate how glucosamine sulfate (GS), chondroitin sulfate (CS), and their combination (GC) could help manage rheumatoid arthritis (RA) in rat models. After inducing RA in rats, we monitored their body weight and paw swelling at different times. The treatments started after confirming the RA model, allowing us to observe their effects on inflammation levels over time.
Our findings showed that only the combination treatment, GC, effectively reduced paw swelling and certain inflammatory markers in the joint tissue. Notably, this combined treatment seemed to target specific bacteria in the gut that may contribute to inflammation. We noticed that GC inhibited a group of bacteria linked to pro-inflammatory responses, providing a potential mechanism for its therapeutic effect.
The gut microbiota appears to play a significant role, as we found that restoring its balance coincided with reduced joint swelling. In summary, the combination of glucosamine and chondroitin sulfate offers a promising avenue for managing rheumatoid arthritis by regulating inflammation and improving gut health.
Our findings showed that only the combination treatment, GC, effectively reduced paw swelling and certain inflammatory markers in the joint tissue. Notably, this combined treatment seemed to target specific bacteria in the gut that may contribute to inflammation. We noticed that GC inhibited a group of bacteria linked to pro-inflammatory responses, providing a potential mechanism for its therapeutic effect.
The gut microbiota appears to play a significant role, as we found that restoring its balance coincided with reduced joint swelling. In summary, the combination of glucosamine and chondroitin sulfate offers a promising avenue for managing rheumatoid arthritis by regulating inflammation and improving gut health.
Read More
8
We explored the effectiveness of a transdermal treatment combining glucosamine sulfate and capsaicin, known as TGC-Plus cream, for managing pain related to rheumatoid arthritis and other chronic joint issues. In a study conducted at a rheumatology outpatient clinic, we observed that a group of 100 patients applied the cream twice daily for 12 weeks. Throughout this period, they also received pharmaceutical care, including helpful advice and support for better adherence to the treatment.
After 12 weeks, the results were encouraging. Patients reported a significant decrease in their pain levels and improved joint function. Specifically, the pain score reduced from an average of 7 to about 3.5, while the limitations in joint movement substantially decreased as well. Additionally, we saw a notable decline in the need for other pain relief medications and fewer visits to the doctor, indicating that the treatment not only helped relieve symptoms but also improved overall quality of life.
It’s important to note that while our findings were promising, the study combined glucosamine sulfate with capsaicin, making it challenging to fully dissect the effects attributed solely to glucosamine. Nonetheless, the supervised usage of TGC-Plus cream seems to provide beneficial outcomes, particularly for those who had struggled to find relief through other means.
After 12 weeks, the results were encouraging. Patients reported a significant decrease in their pain levels and improved joint function. Specifically, the pain score reduced from an average of 7 to about 3.5, while the limitations in joint movement substantially decreased as well. Additionally, we saw a notable decline in the need for other pain relief medications and fewer visits to the doctor, indicating that the treatment not only helped relieve symptoms but also improved overall quality of life.
It’s important to note that while our findings were promising, the study combined glucosamine sulfate with capsaicin, making it challenging to fully dissect the effects attributed solely to glucosamine. Nonetheless, the supervised usage of TGC-Plus cream seems to provide beneficial outcomes, particularly for those who had struggled to find relief through other means.
Read More
8
In our exploration of how glucosamine sulfate may help those with rheumatoid arthritis, we looked at its effects alongside another compound called anserine. We conducted the study on rats, dividing them into different groups to compare results: one group received no treatment, while others were given either glucosamine, anserine, or a combination of both.
Over 45 days, we tracked various markers in the rats' blood and joint tissues to see how these treatments influenced inflammation and oxidative stress. We found that the combination of anserine and glucosamine notably improved levels of important antioxidants and reduced inflammatory markers compared to the other groups.
However, it’s essential to highlight that this study didn't examine glucosamine sulfate alone. By observing its combined effects with anserine, we limited our assessment of glucosamine's standalone benefits. Nonetheless, the results suggest that when paired with anserine, glucosamine could be beneficial for managing some symptoms of rheumatoid arthritis, though more research is needed to understand its isolated effects fully.
Over 45 days, we tracked various markers in the rats' blood and joint tissues to see how these treatments influenced inflammation and oxidative stress. We found that the combination of anserine and glucosamine notably improved levels of important antioxidants and reduced inflammatory markers compared to the other groups.
However, it’s essential to highlight that this study didn't examine glucosamine sulfate alone. By observing its combined effects with anserine, we limited our assessment of glucosamine's standalone benefits. Nonetheless, the results suggest that when paired with anserine, glucosamine could be beneficial for managing some symptoms of rheumatoid arthritis, though more research is needed to understand its isolated effects fully.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Significant health improvement
Glucosamine chondroitin is an excellent supplement. I have back issues and joint pain. After a week of use, my health improved remarkably. My mother took this supplement for rheumatoid arthritis alongside hormones, resulting in a good outcome with pain relief. We sourced this from another manufacturer, and this one is clearly superior in quality and dosage. I highly recommend it.
Read More
9.5
Reduced joint discomfort
This product works! I opted for Now among other brands. It provides excellent dosage with sulphur, sufficient for a three-month course. I bought it for my 56-year-old mother, who has rheumatoid arthritis, and within three weeks, her knees stopped crunching, and morning aches were less severe. We take this alongside collagen powder and multivitamins 55+.
Read More
9.5
Mobility restored
Following Covid, I experienced joint complications. This product has helped me live pain-free and restored my joint mobility, making rheumatoid arthritis a thing of the past.
Read More
9
Effective and affordable
I switched to this instead of the pricey Arthra; it's just as effective, cheaper, and doesn't upset my stomach. With rheumatoid arthritis, my knees and fingers often hurt, but I've noticed a substantial improvement—they bother me less, so I recommend this product.
Read More
8.3
Normal mobility restored
My mum has rheumatoid arthritis and gout. After taking chondroitin, vitamin D3, and calcium citrate, her joint pain significantly decreased, and she regained normal mobility. I will definitely order more as soon as the product is available.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Notarnicola A, Tafuri S, Fusaro L, Moretti L, Pesce V, et al. The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. Adv Ther. 2011;28:894. doi:10.1007/s12325-011-0068-3
- Wang X, Liu D, Li D, Yan J, Yang J, et al. Combined treatment with glucosamine and chondroitin sulfate improves rheumatoid arthritis in rats by regulating the gut microbiota. Nutr Metab (Lond). 2023;20:22. doi:10.1186/s12986-023-00735-2
- Issa AY, ALSalamat HA, Awad WB, Haddaden RM, Aleidi SM. The impact of pharmaceutical care on the efficacy and safety of transdermal glucosamine sulfate and capsaicin for joint pain. Int J Clin Pharm. 2021;43:101. doi:10.1007/s11096-020-01113-1
- Zhao JM, Chen X, Cheng K, Shi Q, Peng K. Anserine and glucosamine supplementation attenuates the levels of inflammatory markers in rats with rheumatoid arthritis. AMB Express. 2020;10:57. doi:10.1186/s13568-020-00987-8
- Dai W, Qi C, Wang S. Synergistic effect of glucosamine and vitamin E against experimental rheumatoid arthritis in neonatal rats. Biomed Pharmacother. 2018;105:835. doi:10.1016/j.biopha.2018.05.136
- Haleagrahara N, Swaminathan M, Chakravarthi S, Radhakrishnan A. Therapeutic efficacy of vitamin E δ-tocotrienol in collagen-induced rat model of arthritis. Biomed Res Int. 2014;2014:539540. doi:10.1155/2014/539540
- Yamagishi Y, Igarashi M, Suzuki A, Suguro S, Hirano SI, et al. Evaluation of the effect of methionine and glucosamine on adjuvant arthritis in rats. Exp Ther Med. 2012;4:640.
- Arafa NM, Hamuda HM, Melek ST, Darwish SK. The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model. Toxicol Ind Health. 2013;29:187. doi:10.1177/0748233711428643
